First Natural Product from Marine Myxobacteria

Although terrestrial myxobacteria have been extensively studied and are known to produce a range of secondary metabolites with a remarkable variety of unusual structures, their marine counterparts have only recently been discovered.

Gabriele M. König and co-workers, University of Bonn, Germany, have isolated a marine myxobacterium from a mud sample from the coast of the island Prerow, Germany. Analysis showed that the bacterium was Enhygromyxa salina, which is closely related to microorganisms previously termed “unculturable”. As this bacterium was found to have persistent antibiotic activity towards gram-positive microorganisms, it was chosen for detailed investigation.

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