Fish peptide could help in battle against cardiovascular disease

A major international review of a peptide originally found in fish that could be used in the battle against cardiovascular disease has been published.

Professor David Lambert from the University of Leicester’s Department of Cardiovascular Sciences contributed to the review, which has been largely written by the International Union of Basic and Clinical Pharmacology (IUPHAR) subcommittee, to pull together the vast literature on Urotensin II (UII), a peptide first isolated from teleost fish.

UII activates a G protein–coupled receptor called UT to modulate a number of signalling pathways including intracellular Calcium. Interestingly, the peptide can constrict some blood vessels yet dilate others.

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